苯胺法制酮基布洛芬工艺改进

摘要

以苯胺为起始原料,经过酰胺化、环合、苄基化、水解、脱胺基、氧化等几步反应,得到产物酮基布洛芬,总收率42.5%。该法原料易得,反应条件温和,操作简单,收率较高,适合于工业化生产。%Ketoprofen was synthesized from anline by amidation, cyclization, benzylation, hydrolysis, deamination and oxidation with an overall yield of 42.5 %. This method has advantages of easy accessible raw materials, mild reaction conditions, convenient procedures, high yield and suitable to industrialization.