2-(2-咪唑基)-(4-正丁氧基)苯甲酰苯胺的合成工艺改进

摘要

Compound of N-[2-(1H-Benzoimidazol-2-yl)-phenyl]-4-butoxy-benzamide has potential antitumor effect as well as excellent bioactivities. The compound was synthesized starting from commercially available raw materials with the ring closing reaction, reduction reaction and acylation reaction as the key steps through six steps in more than 30％ overall yields, the product was characterized by 1 H NMR, 13 C NMR, HR-ESI-MS and found to be in good agreement with its structure.%2-(2-咪唑基)-(4-正丁氧基)苯甲酰苯胺具有潜在的抗肿瘤效应.本文通过改进合成路径,经过关环反应、还原反应以及酰化反应,成功合成了化合物2-(2-咪唑基)-(4-正丁氧基)苯甲酰苯胺(6),六步反应总收率达到30％,且各步反应都能放量反应,反应中间体及目标化合物结构经MS、1 H NMR、13 C NMR确证.