硬脂酸酰胺丙基二甲基烷基季铵盐的合成及性能研究

摘要

The intermediate stearic acid amide propyl dimethyl tertiary amine was prepared by stearic acid and N,N'-dimethyl-1,3-propanediamine.Then the intermediate was reacted with epichlorohydrin,benzyl bromide,1-bromobutane,benzyl chloride,1-bromodecane,glycerin(-e-) α-chlorohydrin,so we got a series of stearic acid amide propyl dimethyl alkyl quaternary ammonium salts.The intermediate and target products were characterized by IR,1 H NMR and ESI-MS,and the surface chemical properties and antibacterial properties of the quaternary ammonium salt products were measured.The results showed that the series of stearic acid amide quaternary ammonium salts had good surface chemical properties,and their cmc could reach 10-4 mol/L.They hadgood antibacterial properties,and had different inhibitory effect on escherichia coli,staphylococcus aureus,enterococcus hirae,Pseudomonas aeruginosa etc.%以硬脂酸、N,N-二甲基-1,3-丙二胺制备了硬脂酸酰胺丙基二甲基叔胺中间体,再与环氧氯丙烷、苄溴、溴丁烷、苄氯、溴癸烷、氯代甘油等季铵化试剂反应,生成一系列硬脂酸酰胺型季铵盐.通过IR光谱,1H NMR,ESI-MS等手段对中间体及目标产物进行表征,并对季铵盐产物的表面化学性能及抗菌性能等进行了测定.结果表明:系列硬脂酸酰胺型季铵盐具有良好的表面化学性能,cmc可达到10-4 mol/L;具有较好的抗菌性能,对大肠杆菌EC、金黄色葡萄球菌SA、海氏肠球菌EH、铜绿假单胞菌PA等菌种具有不同程度的抑制效果,是一种环境友好的抗菌剂.