自拟清肺祛痰止咳方联合沐舒坦对小儿急性肺损伤炎症因子的影响

摘要

Objective To investigate the effect of Qingfei Qutan Zhike Decoction combined with Mucosolvan on inflammatory factors in children with acute lung injury. Methods 92 children with acute lung injury admitted to our hospital from March 2016 to April 2017 were enrolled. The patients were divided into the control group and the observation group according to the random number table, and 46 patients in each group were given mushutan orally.The observation group was given oral Qingfei Qudu Zhike Decoction combined with Mucosolvan oral treatment, after 3 days of treatment, the clinical efficacy of the two groups were observed, and the arterial blood oxygen partial pressure (PaO2) and oxygenation index (PaO2/FiO2) were compared. Pulmonary function indicators: maximum voluntary ventilation (MVV), vital capacity (VC), and one-second expiratory volume (FEV1), inflammatory factors hypoxia-inducible factor-1α (HIF-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) level were observed. Results After 3 days of treatment, the total effective rate of the observation group was 93.48％ higher than 76.09％ of the control group (P＜0.05). PaO2 and PaO2/FiO2 in the observation group were significantly higher than those in the control group (P＜ 0.05). The lung function indexes MVV, VC and FEV1 of the observation group were significantly higher than the control group (P＜0.05). The inflammatory factors HIF-1α, TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P＜0.05). Conclusion Self-made Qingfei Quzhi Decoction combined with Mucosolvan has a good clinical effect on acute lung injury in children, which can improve arterial blood and lung function indexes and reduce inflammation.%目的 探讨自拟清肺祛痰止咳方联合沐舒坦对小儿急性肺损伤炎症因子的影响.方法 选择2016年3月至2017年4月我院收治的92例小儿急性肺损伤患者为对象,按照随机数字表法分为对照组和观察组,每组46例,对照组给予沐舒坦口服治疗,观察组给予自拟清肺祛痰止咳方联合沐舒坦口服治疗,治疗3d后,观察两组的临床疗效,比较动脉气血氧气分压(PaO2)及氧合指数(PaO2/FiO2),肺功能指标最大自主通气量(MVV)、肺活量(VC)和一秒呼气容积(FEV1),炎症因子缺氧诱导因子-1α(HIF-1α)、肿瘤坏死因子α(TNF-α)和白介素6(IL-6)水平.结果 治疗3d后,观察组总有效率93.48％高于对照组的76.09％(P＜0.05).观察组动脉气血指标Pa O2和PaO2/FiO2均显著高于对照组(P＜0.05).观察组的肺功能指标MVV、VC和FEV1均显著高于对照组(P＜0.05).观察组的炎症因子HIF-1α、TNF-α和IL-6显著低于对照组(P＜0.05).结论 自拟清肺祛痰止咳方联合沐舒坦对小儿急性肺损伤具有较好的临床疗效,可改善动脉气血和肺功能指标,减轻炎症反应.