文拉法新缓释片合并认知行为疗法治疗广泛性焦虑症效果观察

摘要

目的：探讨文拉法新缓释片合并认知行为疗法治疗广泛性焦虑症（ GAD）的临床效果。方法采用随机数字表法将92例符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）的GAD患者分为研究组和对照组各46例，研究组给予文拉法新合并认知行为疗法治疗，对照组给予文拉法新治疗，疗程8周。所有患者均采用汉密尔顿焦虑量表（ HAMA）评定疗效。结果治疗2周后，研究组HAMA总评分与治疗前比较差异有统计学意义（P＜0.01），4周后对照组HAMA总评分与治疗前比较差异有统计学意义（P＜0.01）；治疗后4、6、8周末两组HA-MA总评分差异有统计学意义（ P＜0.01）。治疗8周后研究组与对照组有效率分别为93.0％和78.3％，差异有统计学意义（χ2＝3.93，P＜0.05）。结论文拉法新合并认知行为疗法的起效时间和疗效可能均优于单用文拉法新治疗。%Objective To explore the effect of venlafaxine XR combination with cognitive-behavioral therapy(CBT)in Gener-alized Anxiety Disorder(GAD).Methods A total of 92 patients with GAD wererandomly divided into study group(46cases,treated with venlafaxine XR combined with cognitive-behavioral therapy for 8 weeks)and control group(46 cases,treated with venlafaxine XR monotherapy for 8 weeks).All patients were assessed with Hamilton Anxiety Scale(HAMA).Results Compared with before treatment,the difference of total HAMA score was statistically significant(P<0. 01)in study group after 2 weeks,while the difference of total HAMA score was statistically significant(P<0. 01)in control group after 4 weeks. The difference of HAMA scores were statis-tical significant between the two groups after the 4th,6th and 8th week treatment(P<0. 01). After 8 weeks,the effective rate in study group and control group were 93. 0% and 78. 3% respectively,and the difference was statistically significant between the two groups (χ2=3.93,P<0.05).Conclusion Venlafaxine XR combination with CBT may be more effective than venlafaxine therapy alone and works earlier for GAD.