阿尔茨海默病与血管性痴呆患者精神行为症状的对照研究

摘要

Objective To explore the prevalence and difference of kehavioral and psychological symptoms( BPSD)in patients with Alzheimer ˊs disease( AD)and patients with vascular dementia( VD). Methods 102 inpatients with AD and 100 inpatients with VD in accord with Diagnostic and Statistical Manual of Mental disorders,Fourth Edition( DSM-Ⅳ)in Linyi Mental Health Center were enrolled from January,2011 to June,2014. All patients were assessed with Mini Mental State Examination(MMSE)and Neuropsy=chiatric Inventory(NPI). Results The prevalence of BPSD in patients with AD and patients with VD were 92. 16%,86. 00% respec=tively,there was no difference ketween the two groups(χ2 =1. 972,P﹥0. 05). The rate of hallucinations,agitation,apathy,irritakility, akerrant motor kehavior,sleep kehavior in AD group was significantly higher than that in VD group(P﹤0. 05 or 0. 01),while the rate of depression symptoms were more common in VD group than in AD group(P﹤0. 01). Conclusion There is difference of BPSD in patients with AD and patients with VD,and itˊs helpful to distinguish AD and VD patients ky evaluating BPSD.%目的探讨阿尔茨海默病（ AD）与血管性痴呆（ VD）患者精神行为症状（ BPSD）的阳性检出率及差异。方法选取2011年1月-2014年6月在临沂市精神卫生中心住院的痴呆患者，均符合美国精神病学会《精神障碍诊断和统计手册（第4版）》（ DSM-Ⅳ）AD和VD诊断标准，其中AD患者102例，VD患者100例，采用简易精神状态评定量表（ MMSE）及神经精神问卷（ NPI）进行测评。结果 AD和VD患者BPSD阳性检出率分别为92.16%和86.00%，差异无统计学意义（χ2=1.972，P﹥0.05）。AD组幻觉、激越、淡漠、易激惹、异常运动行为、睡眠夜间行为的阳性检出率高于VD组，差异有统计学意义（ P﹤0.05或0.01），VD组抑郁症状检出率高于AD组，差异有统计学意义（ P﹤0.01）。结论 AD和VD患者BPSD存在差异，对BPSD测评可能有助于AD和VD的鉴别。