氯吡格雷联合低分子肝素和阿斯匹林治疗不稳定型心绞痛的疗效观察

摘要

Objective To observe the low molecular weight heparin and aspirin and clopidogrel treatment of unstable angina pectoris. Methods 82 patients with unstable angina were randomly divided into treatment group and control group 41 patients, two groups were given nitroglycerin, β-blockers， calcium channel blockers， ACEI and other conventional therapy, the treatment group conventional therapy with clopidogrel plus low molecular weight heparin therapy were evaluated 14 days after the clinical efficacy. Results The effective rate was 90. 24％ , significantly higher than the treatment group, total effective rate of ECG improvement was also significantly higher, and after treatment, angina frequency and duration was shortened improvement in the treatment group than the control group ( P ＜ 0. 05 ) . Conclusion Based on the conventional drug Clopidogrel, low molecularweight heparin is effective treatment of unstable angina, angina duration and number of episodes also decreased significantly lessadverse reaction, should be widely promoted and applied clinically.%目的 观察氯吡格雷联合低分子肝素和阿斯匹林治疗不稳定型心绞痛的疗效.方法 82例不稳定型心绞痛患者随机分为治疗组和对照组各41例,两组均给予硝酸甘油、β受体阻滞剂、钙离子桔抗剂、ACEI等常规治疗,治疗组在常规治疗基础上加用氯吡格雷联合低分子肝素,治疗14d后评价两组的临床疗效.结果 治疗组的有效率为90.24%,明显高于对照组,治疗组的心电图改善的总有效率也明显高于对照组,且两组治疗后心绞痛的发作次数及持续时间明显缩短,其中治疗组的改善情况优于对照组(P<0.05).结论 在常规用药基础上联合氯吡格雷、低分子肝素治疗不稳定性心绞痛疗效确切,心绞痛持续时间和发作次数也明显减少,不良反应少,值得临床广泛推广和应用.