多发性骨髓瘤血清胱抑素C水平与肿瘤负荷关系的临床研究

摘要

Objective The aim of this study was to evaluate the serum levels of cystatin-C in multiple myeloma patients, explore possible correlations with clinical data, including ISS stage、 β2-microglobulin、 advanced lytic lesions.Methods We measured serum cystatin-C、 β2 -microglobulin in 32 newly diagnosed, in 8 patients with relapsed disease, using automatic biochemistry analyzer detection.According to skeleton ECT classify- grading of osteolytic lesion.Results In multiple myeloma patients, cystatin-C was showed strong correlations with advanced ISS stage、high β2-microglobulin、 extensive bone disease.Conclusion Serum cystatin-C reflects tumor burden, as a potential indicator to assess.%目的 探讨血清胱抑素C(Cys-C)与多发性骨髓瘤(MM)患者ISS分期、β-微球蛋白、溶骨性损害等指标的关系.方法 收集40例多发性骨髓瘤患者作为研究对象,测定他们的血清Cys-C、血肌酐(Scr)、β2-微球蛋白.采用核素全身骨显像(骨ECT)现察患者的溶骨性病变部位数.结果 血清Cys-C水平与ISS分期晚,血β2-微球蛋白升高以及溶骨性病变进展密切相关.结论 本研究表明多发性骨髓瘤患者血清Cys-C水平与肿瘤负荷及溶骨性损害的密切相关,可作为评价肿瘤负荷的潜在指标.