To explore the clinical efficacy of gonadotropin releasing hormone analogues (CnRHa) on idiopath-ic central precocious puberty(ICPP) in girls. Methods Total 51 girls with ICPP were selected,and CnRHa was given to them for 1 ～2year. Peak of LH and FSH、estradiol、 uterus and ovary volume were observed before and after treatment. And body mass in-dex、bone age、bone age/age、growth velocity 、predicted adult height were compare on variable treatment. Results The Peak of LH and FSH were significant lower than those before treatment(P<0. 01) ;bone age/age-,growth velocity were significant lower than those before treatment ( P < 0.05); predicted adult height was higher than that before treatment, and there was significant difference (P<0.05). Conclusion CnRHa could inhibit hypothalamus-hypophysis-gonadal axis to cure ICPP,but there are still unresolved questions about the effects on the actual final adult heigh that future studies will need to address.%目的 比较分析促性腺激素释放激素类似物(GnRHa)治疗女童特发性中枢性性早熟(ICPP)的临床疗效.方法 51例女童ICPP患儿用GnRHa治疗,疗程1～2年,观察治疗前后促黄体生成素峰值(P-LH)、促卵泡刺激素峰值(P-FSH)、雌二醇(E2)、子宫容积、卵巢容积以及随疗程变化体重指数(BMI)、骨龄(BA)、骨龄与生活年龄比值(BA/CA)、生长速率(GV)、预测成人身高(PAH)的动态变化.结果 治疗前后促黄体生成素峰值、促卵泡刺激素峰值比较,差异有统计学意义(P＜0.01)；治疗前后骨龄与生活年龄比值、生长速率比较,差异有统计学意义(P＜0.05)；治疗前后预测成人身高有提高趋势,差异有统计学意义(P＜0.05). 结论 GnRHa能有效抑制下丘脑-垂体-性腺轴治疗ICPP,但其促身高增长作用有待进一步研究.
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