目的 了解男女神经心理学和神经内分泌功能之间的相关性,为认知功能的性别差异生物学基础提供依据.方法 对年龄在16 ～75岁的健康成人156例(男64例、女92例)进行神经心理测验,包括部分WAIS智力测验项目、WMS逻辑记忆和视觉记忆测验、STROOP字色干扰测验、词汇流畅性测验、连线测验、汉诺塔木块移动测验(TOH)、威斯康星卡片分类测验改良版(M-WCST).同时对下丘脑-垂体-性腺轴激素包括雌二醇(E2)、孕酮(P)、睾丸酮(T)、黄体生成素(LH)、促卵泡素(FSH)、泌乳素(PRL)和下丘脑-垂体-肾上腺轴激素包括促肾上腺皮质激素(ACTH)、皮质醇(PTC)进行测定.结果 男女在认知功能、神经内分泌水平方面存在明显差异.男女神经内分泌水平和认知功能的相关项目稍有不同,但两者的ACTH、PTC与记忆功能相关,E2、T、LH、FSH等性激素与很多方面的认知功能如注意、记忆、思维分析能力、执行功能相关.结论 健康成人的神经内分泌功能与神经心理功能之间存在相关性.%Objective To investigate the correlation between neuropsychological and neuroendocrine functions in healthy adult . So provide the biological basis for cognitive differences in different gender. Methods 156 healthy adults (64 male, 92 female) at the age of 16-75 did neuropsychological tests, including the WAIS intelligence test project, WMS logical memory and visual memory test, STROOP Word-Color interference test, word fluency test, trail making test, tower of Hanoi block mobile test (TOH) , Modified Wisconsin Card Sorting Test (M-WCST). At the same time measured the hypothalamus-pituitary-gonadal axis hormones including estradiol (E2) , progesterone (P), testosterone (T), luteinizing hormone (LH), follicle-stimulating hormone ( FSH) , prolactin ( PRL) and the hypothalamus-pituitary-adrenal axis hormones including adrenocorticotropie hormone ( ACTH) , cortisol (PTC). Results There were significant differences in cognitive function and neuroendocrine hormones between male and female. Both neuroendocrine and cognitive function related projects are slightly different between male and female, both ACTH, PTC were correlated with memory function, E2, T, LH, FSH and other sex hormones were correlated with many aspects of cognitive functions such as attention, memory, thinking analysis ability, executive function. Conclusion There has been correlation in neuroendocrine function and neuropsychological function in healthy adult.
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