Objective To observe the effect of creatine phosphate sodium( CP)in the treatment of hypoxic-ischemic mycardial damage in neonates. Methods From December 2009 to December 2011, 69 neonates with hypoxic-ischemic myocardial damage were randomly divided into treatment group ( n = 35 ) and control group ( n = 34 ) . All the neonates were treated with conventional therapy,and on this basis,the treatment group were Ven with CP inrtravenously, 1. 0 g every time,once a day and 7 ~ lOdays as a course. The changed of symptoms, physical signs, ECG and myocardial enzymogram were observed during the treatment. Results The total effective rate was 91.4% in the treatment group and 76. 5% in the control group. Corresponding ECG changes were also observed in all infants. There is significant difference between the two groups on the myocardial enzymogram ( P < 0. 05 ) . Conclusion CP has notable curative effect in the treatment of neonatal hypoxia-ischemic myocardial damage, and is safe and effective.%目的 观察磷酸肌酸钠治疗新生儿缺氧缺血性心肌损害的疗效.方法 选择2009年12月～2011年12月,本院新生儿科收治的69例新生儿缺氧缺血性心肌损害的患儿随机分为治疗组35例,对照组34例.两组均给予常规治疗,在此基础上,治疗组给予静脉滴注磷酸肌酸钠,1.0g/次,1次/d,7～10d为1个疗程,观察两组患儿治疗前后症状、体征以及心电图、心肌酶谱的变化.结果 治疗组的总有效率为91.4%,明显高于对照组的76.5%;所有患儿心电图改变均消失;治疗组与对照组治疗后心肌酶谱比较,差异有统计学意义(P<0.05).结论 新生儿缺氧缺血性心肌损害检测指标特异敏感,磷酸肌酸钠治疗新生儿缺氧缺血性心肌损害疗效显著、安全有效.
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