复方丹参治疗妊娠期肝内胆汁淤积症所致新生儿脑损伤的临床观察

摘要

Objective To observe observation of brain injury induced by intrahepatic cholestasis of pregnancy( ICP) with compound danshen intravenous in newborn. Methods 91 newborns were divided into two groups randmly. Both groups received the conventional treatments. Additionaly,the observation group(48 infants) were assistedly treated with compound danshen intrave-nous drip,14 days as a course. Results After treatment Serum CK-BB and NSE levels were significantly lower in observation group (P<0. 05). The NBNA score was markedly higher in the observation group than in the control group,showing a significant difference between two groups(P<0. 05). Conclusion Compound danshen has notable curative effect in the the treament of brain injury induced by ICP in newborn and is safe and effective.%目的：观察复方丹参治疗妊娠期肝内胆汁淤积症所致新生儿脑缺氧损伤的疗效。方法364例因母亲患妊娠期肝内胆汁淤积致新生儿脑损伤的患儿随机分为观察组192例和对照组172例,观察组在对照组常规治疗的基础上加用复方丹参注射液2ml/(kg·d),连用14d。所有患儿均于治疗前、后采静脉血检测NSE和CK-BB,并进行NBNA评分。结果治疗后观察组血清中NSE和CK-BB浓度明显低于对照组,比较差异有统计学意义( P<0．05)；治疗后观察组的NBNA评分明显高于对照组,比较差异有统计学意义( P<0．05)。结论复方丹参治疗妊娠期肝内胆汁淤积症所致新生儿脑缺氧损伤值得重视。