Objective To study the comparison of intraoperative anesthetic effect and safety of different doses of sufen-tanil in patients with cardiovascular ERCP. Method 90 cases of ASA grade Ⅱ~Ⅲ patients with cardiovascular ERCP, who were randomly divided into 3 groups(n=37 cases):group S1,group S2,group S3. Each group was infused dexmedetomidine 10min by intravenous after 0. 5ug/kg, respectively composited magnesium sulfate 10mg/kg and sufentanil 0. 1ug/kg, 0. 12ug/kg, 0. 15ug/kg with intravenous injection slowly. Then the target plasma concentration of etomidate set the plasma concentration as 0. 5ug/ml. Each group was treated by magnesium sulfate continuous infusion of 6mg/(kg·h) + of the target plasma concentration of etomidate of 0. 3 ~0. 5ug/ml to maintain anesthesia. According to BIS,the plasma concentration of etomidate was adjusted to maintain the BIS at about 55 or so. Observed and recorded MAP、HR、RPP、SpO 2 and BIS at different time such as before anesthe-sia, after induction, when a mirror was inserted, endoscopic placement of duodenal papilla, recovery etc. . Add up the time of the surgery, anesthesia recovery,orientation recovery and the incidence rate of untoward reaction. Results All patients were success-fully completed the surgery. MAP and HR of group S2 and group S3 were significantly lower than those of group S1 ( P<0. 05 ) when the mirror was inserted and the mirror was in duodenal papilla. The heartbeat bradycardia of group S3 was significantly high-er than that in S2 group(P<0. 05)during the whole surgery. RPP:The RPP of group S2 and S3 were significantly lower than those of group S1(P<0. 01)when the mirror was in the duodenal papilla. BIS:After anesthesia induction to the mirror inserted the duo-denum,the BIS of group S3 was significantly lower than that of S1 at each time point(P<0. 01); when intubated:S3展开▼
