不同维持剂量咖啡因治疗早产儿呼吸暂停的疗效观察

摘要

目的 探讨不同维持剂量咖啡因治疗早产儿呼吸暂停的疗效. 方法 将我院NICU 2012年1月至2014年11月3年间收治并符合条件的77例出现呼吸暂停的早产儿随机分为3组,A组23例,B组28例,C组26例,三组均在常规治疗(按摩脊背,弹足底,俯卧位,若不能缓解并出现发绀时予以复苏囊正压给氧)的基础上,使用咖啡因治疗,先给予20mg/kg负荷量, 24h后三组分别给予5mg/kg、10mg/kg、15mg/kg维持. 结果 B、C两组发生呼吸暂停的次数明显减少,治疗时间较A组明显缩短,停药时间提前,A、B两组相比,A、C两组相比差异有统计学意义( P<0. 05 ); B、C两组相比差异无统计学意义(P>0. 05). 结论 早产儿呼吸暂停使用咖啡因治疗先用20mg/kg负荷量后,维持量用10mg/kg效果明显.%Objective To explore the curative effect of different maintenance dose plus caffeine for the treatment of pre-mature infant apnea. Methods From January 2012 - November 2014 treated 80 cases in NICU with apnea of premature infants were randomly divided into 3 groups, group A (23 cases), group B (28 cases), group C (26 cases), three groups were received routine therapy ( massage back, playing A foot, the prone position, if can't ease and cyanosis when recovery capsule positive pres-sure to oxygen) , on the basis of using caffeine treatment, providing first 20 mg/kg body weight load. 24 hours later the three groups were given 5 mg/kg, 10 mg/kg, and 15 mg/kg. Results The rate of apnea was significantly reduce in group B and C and the treatment time was shortened obviously compared with group A. A, B, compared two groups A and C was statistically significant difference in two groups, P<0. 05;B, C, there was no statistically significant difference in two groups(P>0. 05). Conclusion The premature infant apnea using caffeine after treatment with 20 mg/kg load first, maintain the quantity with 10 mg/kg body weight.