黛力新联合帕罗西汀治疗脑卒中后抑郁的临床观察

摘要

目的 观察黛力新联合帕罗西汀治疗脑卒中后抑郁患者的临床疗效. 方法 按照随机数字表法将我院收治的90例脑卒中后抑郁患者随机分为观察组和对照组. 两组患者均行脑卒中常规治疗,观察组在常规治疗基础上联合应用黛力新和帕罗西汀,对照组在常规治疗基础上单纯应用黛力新,28d为1个疗程. 观察对比两组患者的临床疗效、汉密顿抑郁量表( HAMD)评分、日常生活能力量表( ADL)评分、抑郁自评量表SDS、神经功能缺失评分NIHSS等情况. 结果疗程结束后,观察组总有效率达93. 3%,对照组总有效率为75. 6%,两组比较差异有统计学意义( P＜0. 05 );且观察组患者治疗后7d、28d的HAMD评分、ADL、SDS评分优于对照组,NIHSS优于对照组,两组比较差异有统计学意义(P＜0. 05).结论 联合应用黛力新和帕罗西汀治疗PSD,可有效改善患者抑郁,促进神经功能恢复,提高认知能力,比单纯应用黛力新的疗效更为显著,值得临床推广应用.%Objective To observe the clinical efficacy of Deanxit combined with Paroxetine in the treatment of patients with depression after stroke. Methods According to the random number table method 90 stroke patients admitted to our hospital for depressed patients were randomly divided into observation group and control group. Two groups of patients underwent conven-tional stroke treatment,the observation group in the conventional therapy combined with Deanxit and Paroxetine,the control group on the basis of conventional therapy with Deanxit,28d for 1 course. To observe the clinical curative effect,compared two groups of patients with Hamilton Depression Scale( HAMD) score;activity of daily living scale( ADL) scores,SDS and NIHSS etc. Results After treatment,total effective rate of observation group is as high as 93. 3%,the control group the total effective rate was 75. 6%, there was significant difference between two groups(P＜0. 05);and the patients in the observation group after treatment,7d,28d HAMD score,ADL score decreased significantly than that in the control group,and NIHSS score increased significantly than that in the control group,there was significant difference between two groups(P＜0. 05). Conclusion The combined use of Deanxit and Paroxetine in the treatment of depression in patients with PSD, can effectively improve,promote the recovery of neurological func-tion,improve cognitive ability, than the results of simple application of Deanxit is more remarkable,worthy of clinical application.