盐酸羟考酮缓释片联合即释吗啡片对中重度晚期癌痛患者疼痛程度、便秘症状及生活质量的影响

摘要

目的 探讨盐酸羟考酮缓释片联合即释吗啡片对中重度晚期癌痛患者疼痛程度、便秘症状及生活质量的影响.方法 选取86例中重度晚期癌痛患者随机分为对照组和观察组,对照组患者仅用盐酸羟考酮缓释片进行治疗,观察组患者在此基础上联合即释吗啡片治疗,治疗时间均为10d,记录患者治疗前后疼痛程度、便秘症状及生活质量的情况变化.结果 与治疗前相比,两组患者治疗后的VAS评分显著降低,差异有统计学意义(P<0.05);观察组治疗后的VAS评分要低于对照组,差异有统计学意义(P<0.05).两组患者便秘症状评分中排便困难、粪便形状、排便时间、下坠、不尽、胀感、排便频度、腹胀及便秘症状总分数相比,差异无统计学意义(P>0.05).两组患者治疗后的生理状况、功能状况、社会功能、心理状况及精神状况评分与治疗前比较分数明显升高,差异有统计学意义(P<0.05),且观察组各评分均要高于对照组,差异有统计学意义(P<0.05).结论 对中重度癌痛患者进行盐酸羟考酮缓释片联合即释吗啡片治疗,能有效缓解患者疼痛,改善便秘症状,提高患者生活质量.%Objective To investigate the influence of Oxycodone Hydrochloride extended release tablets combined with Morphine immediate release tablets on pain degree,constipation and living quality of patients with moderate and severe terminal cancer pain.Methods 86 cases of patients with moderate and severe terminal cancer pain were selected and randomly divided in-to control group and observation group.Patients in control group were treated by sole Oxycodone Hydrochloride extended release tablets and patients in observation group were treated by Morphine immediate release tablets in addition to the basis of control group,both 10 days of treatment course.Changes in pain degree,constipation and living quality of patients before and after treat-ment were recorded.Results Compared with conditions before treatment,VAS scores of both groups reduced significantly after treatment,with a statistically significant difference(P<0.05).Post-treatment VAS scores of observation group was lower than con-trol group,with a statistically significant difference(P<0.05).As for constipation symptom scoring,total scores of defecation diffi-culties,stool shape,defecation time,pendant feeling,unthorough feeling,bulge feeling,defecation frequency,abdominal distension and constipation in the two group showed no statistically significant difference(P>0.05).The physiological condition,functional status,social function,psychologic status and mental status scores of both groups all increased after treatment compared with those before treatment,with a statistically significant difference(P<0.05).Furthermore,each scores of observation group were all higher than corresponding scores of control group,the difference being statistically significant(P<0.05).Conclusion The therapy of Oxycodone Hydrochloride extended release tablets combined with Morphine immediate release tablets aimed at patients with moder-ate and severe cancer pain,can effectively relieve pain,improve constipation symptoms and promote living quality.