雌激素受体孕激素受体及人表皮生长因子受体2在脑膜瘤中的表达及意义

摘要

Objective To study the relationship of the expression of estrogen receptor (ER) and progester-one receptor (PR) and human epidermal growth factor receptor 2 (HER2) and clinical pathology and prognosis of meningioma . Methods Using of S-P immunohistochemical methods to test the expression of ER ,PR ,and HER2 receptor of 33 cases of meningioma organization ,analyzing their relationship with the benign and malignant tumor . Results The expression rate of ER ,PR and HER2 in meningioma was 3% (1/33) ,61% (20/33) and 21% (7/33) ,re-spectively .The PR expression rate of the benign tumor was 72% (18/25) among them ,the ominous benign ex-pression rate of patients was 25% (2/8) .The difference had statistical significance (χ2 = 5 .607 ,P =0 .018) . HER2 expression rate was 12% (3/25) ,patients with benign ominous expression rate was 50% (4/8).The difference was significant after statistics processing (χ2 = 5 .236 ,P=0 .022) .Conclusion The expression of ER is not related to meningioma ,PR and HER2 expression are associated with meningioma pathological nature ,which can be used as important reference index of prognosis and treatment for meningioma .%目的：探讨雌激素受体（ER）、孕激素受体（PR）及人表皮生长因子受体2（HER2）的表达与脑膜瘤临床病理和预后的关系。方法采用链霉素抗生物素蛋白-过氧化物酶（SP）法检测33例脑膜瘤组织中 ER、PR及HER2受体的表达，分析它们与肿瘤良恶性的关系。结果 ER在脑膜瘤组织中的表达率为3％（1/33）， PR表达率为61％（20/33），HER2表达率为21％（7/33）。其中PR在良性患者表达率为72％（18/25），非良性患者表达率为25％（2/8），表达率差异有统计学意义（χ2＝5．607，P ＝0．018）。HER2在良性患者表达率12％（3/25），非良性患者表达率为50％（4/8），差异具有统计学意义（χ2＝5．236，P ＝0．022）。结论 ER表达与脑膜瘤无关，PR及 H ER2表达与脑膜瘤病理性质有关，可作为脑膜瘤预后判定及治疗的重要参考指标。