Objective To analyze the C‐peptide and osteocalcin expression levels in type 2 diabetes mellitus patients complicated with osteoporosis .Methods A total of 96 type 2 diabetes mellitus patients from February 2013 to January 2014 in our hospital were enrolled .Based on bone density and osteoporosis diagnosis criteria ,they were divided in type 2 diabetes mellitus complicated with osteoporosis as the observation group ,and type 2 diabe‐tes mellitus without osteoporosis as the control group .TG ,FBG ,TC ,LDL‐C ,HDL‐C ,P2 hBG ,fasting C‐pep‐tide ,osteocalcin and postprandial 2 h C‐peptide levels were detected .The bone mineral density of trochanter ,fem‐oral neck and lumbar 1‐4 area were measured .Results Age ,clinical course and other general information has no significant difference between two group (P>0.05);TG ,FBG and other biochemical indicators of the two groups also has no statistical significance (P>0.05);Trochanter bone mineral density (0.62 ± 0.14 g/cm2 ) in the obser‐vation group was significantly lower than that of the control group ,and the difference was statistically significant (t=8.44 , P< 0.05) .BMD of the femoral neck and lumbar 1‐4 area in the observation group were lower than those of the control group ,and the difference was statistically significant (t=8.07 ,t=11.41 ,P<0.05);fasting C‐peptide ,postprandial 2 h C‐peptide and osteocalcin were significantly lower than those in the control group ,and the difference was statistically significant (t=3.26 ,t=7.51 ,t=5.97 ,P<0.05) .Conclusion Bone mineral den‐sity in patients with type 2 diabetes mellitus is closely related to pancreatic beta‐cell function .C‐peptide and osteo‐calcin can be used as important reference index for type 2 diabetes mellitus patients with high risk of osteoporosis .%目的：分析C肽及骨钙素在2型糖尿病合并骨质疏松患者中的表达水平。方法以2013年2月至2014年1月在我院内分泌科住院治疗的96例2型糖尿病患者为研究对象，根据骨密度及骨质疏松诊断标准将2型糖尿病合并骨质疏松患者为观察组，单纯2型糖尿病患者为对照组，对2组患者甘油三酯（T G ）、空腹血糖（FBG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL‐C）、高密度脂蛋白胆固醇（HDL‐C），餐后2 h血糖（P2 hBG）、空腹C肽、骨钙素（BGP）及餐后2 h C肽水平进行检测。对大转子、股骨颈、腰椎1～4区骨密度进行测定。结果2组患者年龄、病程等一般资料差异无统计学意义（P＞0.05）；TG、FBG等生化指标之间2组差异无统计学意义（P＞0.05）；观察组大转子骨密度为（0.62±0.14）g／cm2显著低于对照组，差异有统计学意义（t＝8.44，P＜0.05）。观察组患者股骨颈及腰椎1～4区骨密度均较对照组低，差异均有统计学意义（ t＝8.07，t＝11.41，P＜0.05）；空腹C肽、餐后2 h C肽及骨钙素含量显著低于对照组，差异具有统计学意义（ t＝3.26，t＝7.51，t＝5.97，P＜0.05）。结论2型糖尿病患者骨密度与胰岛B细胞功能紧密相关，C肽及骨钙素等指标可以作为2型糖尿病合并骨质疏松高危人群的重要参考指标。
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