Epidemiological study shows that the risk of fracture occurrence in patients with type 2 diabetes is higher than that in the healthy population. Therefore, enough attention to osteoporosis and fracture complication should be paid by patients with type 2 diabetes. Studies at the molecular mechanism level shows that the occurrence of type 2 diabetes with osteoporosis may be associated with changes of insulin-like growth factor 1, glucose toxicity, sclerostin, osteocalcin, oxidative stress, and other metabolic pathways. Insulin-like growth factor 1 is a regulator of bone formation. It plays an important role in the regulation of bone remodeling process mediated by osteoblasts and osteoclasts. Osteocalcin is a non-collagen protein produced by osteoblasts. It reflects the activity of osteoblasts, and it is often used as a specific marker of bone formation and bone turnover. Studies have shown that insulin-like growth factor 1 stimulates osteocalcin synthesis in a dose-dependent manner. This paper reviews the effect of insulin-like growth factor 1 on the expression of osteocalcin in type 2 diabetic patients with osteoporosis, the correlation between osteocalcin and insulin like growth factor 1 in type 2 diabetic patients, the early diagnosis and treatment of osteoporosis, prevention of fractures, and the quality of life of the patients.%随着流行病学的调查研究发现,2型糖尿病患者与健康人群相比,其罹患骨折事件的发生率明显增高,所以骨质疏松及骨折等并发症需引起2型糖尿病患者的足够重视.在分子机制层面的研究显示,2型糖尿病合并骨质疏松的发生可能与胰岛素样生长因子1、葡萄糖毒性、硬骨素、骨钙素及氧化应激等多种代谢途径的改变有关.胰岛素样生长因子1是骨形成的调节因子,在调节成骨细胞和破骨细胞介导的骨骼重建过程中起着重要的作用.骨钙素是由成骨细胞产生的一种非胶原蛋白,能够反映成骨细胞的活性,常作为骨形成和骨转换的特异性指标.有研究显示,胰岛素样生长因子1以浓度依赖方式刺激骨钙素的合成增加,本文试就胰岛素样生长因子1对2型糖尿病合并骨质疏松中骨钙素表达的影响做一综述,探讨在2型糖尿病合并骨质疏松患者中胰岛素样生长因子1与骨钙素之间的相关性,以期对2型糖尿病合并骨质疏松患者能够进行早期诊断及治疗,预防骨折事件的发生,提高患者生活质量.
展开▼
