体质量指数与脑梗死的相关性研究

摘要

目的 探讨体质量指数(BMI)对脑梗死的影响.方法 以参加2006-2007年开滦集团职工健康查体的30~70岁在职及离退休职工101510例作为研究对象,排除BMI缺失1470例、脑梗死病史者2171例、恶性肿瘤351例,最终纳入BMI统计分析者97518例.依据BM I将总人群分3组:第1组:BMI<24 kg/m2;第2组:BMI 24~27.9 kg/m2;第3组:BMI≥28 kg/m2.采用COX比例风险模型分析BMI对脑梗死事件的风险比.结果 脑梗死的发生率随着BMI增加呈上升趋势,分别为2.0%,3.1%,3.5%(趋势P<0.05).Cox比例风险模型分析显示,与正常体质量者相比,超重者和肥胖者脑梗死风险比(HR)分别为41%,48%(P<0.05).结论 BM I是脑梗死发生的独立危险因素.%Objective The effect of body mass index(BMI)on cerebral infarction was discussed.Methods In 2006--2007,101 510 participants took part in the health physical examination of the Kailuan Group,exclu-ding the loss of BMI(n=1 470),cerebral infarction(n=2 171),malignant tumor(n=351)and finally 97 518 were included in the statistical analysis.According to BMI,the group was divided into three groups:the normal weight:BMI<24 kg/m2;overweight:BMI 24-27.9 kg/m2;obesity:BMI≥28 kg/m2.The risk ratio of BMI to cerebral infarction was analyzed using the COX proportional hazards model.Results The incidence of cerebral in-farction increased with the increase of BMI,the result was 2.0%,3.1%,3.5%(P<0.05),respectively.The Cox proportional risk model analysis showed that compared with the normal weight group,the overweight and o-besity groups were more likely to have a cerebral infarction,and the HR were 41% and 48% respectively(P<0.05).Conclusion BMI is an independent risk factor for cerebral infarction.