目的:探讨血清卵泡抑素(follistatin,FS)、糖链抗原125(carbohydrate antigen125,CA125)联合检测在卵巢型子宫内膜异位症与卵巢良性肿瘤鉴别诊断中的应用价值。方法:选取2012年3月至2014年6月期间我院确诊治疗的卵巢型子宫内膜异位症患者38例作为异位组,同期选取卵巢良性肿瘤36例作为良性组,统计分析并采用电化学发光免疫法检测所有患者血清中FS、CA125表达水平。结果:异位组患者血清中FS、CA125表达水平明显高于良性组(P<0.05);在FS=1.53 mg/L时,对卵巢型子宫内膜异位症与卵巢良性肿瘤的鉴别诊断敏感度为61.36%,特异度为86.54%,准确度为84.51%,在CA125=25.42 U/ml时,鉴别诊断敏感度为83.32%,特异度为85.18%,准确度为90.25%,二者联合的鉴别诊断敏感度为93.26%,特异度为94.41%,准确度为97.14%。在鉴别诊断敏感度、特异度和准确度方面,FS联合CA125检测>CA125检测>FS检测(PCA125 detection >FS detection (P<0.05).Conclusion: FS and CA125 levels can be used as important reference indexes for the differential diagnosis of ovarian endometriosis and benign tumor, while the joint detection shows higher sensitivity, speciifcity and accuracy and is worthy of further clinical promotion.
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