多巴胺受体激动剂在治疗不宁腿综合征中的临床应用

摘要

Restless legs syndrome (RLS) is characterized by uncomfortable sensations and irresistible urges to move one’s legs, which is usually worse during the rest or sleep and can be relieved by movement. The pathophysiologic mechanism of RLS may be closely related to dopaminergic system and the use of levodopa and dopaminergic agonists for its treatment is effective, in which the ifrst choice is dopaminergic agonists. Dopaminergic agonists are well tolerant in moderate and severe RLS, however, the adverse reactions such as augmentation and rebound should be taken into consideration in long-term treatment.%不宁腿综合征主要表现为肢体感觉异常及难以控制的肢体活动，多在休息、睡眠时加重而在活动后缓解，患者还常伴有失眠等睡眠障碍。不宁腿综合征的发生与多巴胺能系统异常密切相关，使用左旋多巴和多巴胺受体激动剂治疗有效。其中，多巴胺受体激动剂是治疗不宁腿综合征的一线用药，治疗中、重度不宁腿综合征的疗效较好，患者的耐受性也佳，但长期使用时需注意患者症状加重、反跳等不良反应。