TCT和HR-HPV DNA检测对宫颈病变筛查的价值

摘要

Objective:To investigate the value of thinprep cytology test (TCT) and high-risk human papilloma virus DNA (HR-HPV DNA) detection in the screening of cervical lesions so as to provide a theoretical basis for the government to formulate the vaccine prevention policy. Methods:Two hundred and forty-three women diagnosed or examined in our hospital were selected, to whom TCT and the detection of HR-HPV DNA were performed and their results were analyzed. Results:The speciifcity, positive predictive value and diagnosis rate were obviously higher by the combined detection of TCT and HR-HPV DNA than by single detection of HR-HPV DNA and their differences had statistical significance (P<0.05). Conclusion:The combined detection of TCT and HR-HPV DNA can improve the diagnosis level of cervical lesions and early cervical cancer, reduce the rate of misdiagnosis and has important signiifcance for the early screening of cervical lesions.%目的：探讨液基薄层细胞学检测(TCT)和高危型人乳头瘤状病毒DNA(HR-HPV DNA)检测对宫颈病变筛查的价值，为政府制定疫苗的预防政策提供理论依据。方法：选取在我院就诊或体检的妇女243例，均行TCT、HR-HPV DNA检测，分析其检测结果。结果：TCT+HR-HPV DNA联合检测的特异性、阳性预测值和诊断符合率均明显高于HR-HPV DNA单项检测，差异具有统计学意义（P＜0.05）。结论：TCT和HR-HPV DNA联合检测可提高宫颈病变及早期宫颈癌的诊断水平，降低漏诊率，对宫颈病变的早期筛查具有重要意义。