大承气汤对35例严重创伤患者胃肠功能障碍的治疗效果

摘要

目的：探讨大承气汤治疗严重创伤患者胃肠功能障碍的临床疗效。方法：选取2014年1月—2015年7月我院收治的严重创伤患者67例，按随机数字表法分为观察组（n=35）和对照组（n=32），对照组给予常规治疗，观察组给予以大承气汤为主方的中医辨证治疗，比较两组患者治疗后胃肠功能及相关实验室指标改善情况。结果：观察组患者MODS发生率和死亡率均明显低于对照组（P＜0.05）；两组患者治疗后胃肠疾病中医症状评分及血清TNF-a、PCT、DAO水平均明显较治疗前降低，且以观察组患者降低更显著（P＜0.05）。结论：大承气汤治疗严重创伤患者胃肠功能障碍具有较好的疗效，可显著降低MODS发生率，其机制可能与抑制机体炎症反应、纠正胃肠功能障碍有关。%Objective:To discuss the efifcacy of Dachengqi decoction on gastrointestinal dysfunction in the treatment of patients with severe trauma.Methods: Sixty-seven cases of patients with severe trauma were selected and randomly divided into an observational group (n=35) primarily receiving Dachengqi decoction and a control group (n=32) receiving conventional therapy, and the improvement of gastrointestinal function and its related laboratory parameters were compared between the two groups after treatment.Results:The incidence of MODS and mortality was signiifcantly lower in the observational group than control group (P<0.05). The scores of clinical symptoms of gastrointestinal disease and the levels of serum TNF-a, PCT, DAO of all the patients were signiifcantly lower after treatment than before (P<0.05), and furthermore they were more signiifcantly reduced in the observational group (P<0.05).Conclusion: Dachengqi decoction for the treatment of gastrointestinal dysfunction in patients with severe trauma has good effectiveness and can signiifcantly reduce the incidence of MODS, the mechanism of which may be related to inhibiting the body’s inlfammatory response and correcting gastrointestinal dysfunction.