隔姜灸治疗多发性骨髓瘤化疗所致骨髓抑制疗效观察

摘要

目的 观察隔姜灸治疗多发性骨髓瘤化疗后骨髓抑制的临床疗效,探讨隔姜灸疗法对化疗毒副反应的防治作用.方法 将44例多发性骨髓瘤化疗后骨髓抑制患者随机分为治疗组和对照组,每组22例.治疗组采用隔姜灸治疗,对照组采用口服利可君片.两组均治疗14 d.观察两组治疗前、治疗第7天、治疗第14天、治疗后1星期白细胞数目的变化情况,并比较两组恶心呕吐发生率和临床疗效.结果 治疗组总有效率为81.8%,对照组为63.6%,两组比较差异具有统计学意义(P<0.05).两组治疗第7天白细胞计数与同组治疗前比较,差异均有统计学意义(P<0.05);治疗组治疗第7天白细胞计数与对照组比较,差异具有统计学意义(P<0.05).两组治疗第14天白细胞计数与同组治疗第7天比较,差异均具有统计学意义(P<0.05);治疗组治疗第14天白细胞计数与对照组比较,差异具有统计学意义(P<0.05).两组治疗后1星期白细胞计数与同组治疗第14天比较,差异均无统计学意义(P>0.05);治疗组治疗后1星期白细胞计数与对照组比较,差异无统计学意义(P>0.05).治疗组治疗后恶心呕吐发生率明显低于对照组(P<0.05).结论 隔姜灸能有效治疗多发性骨髓瘤化疗后的骨髓抑制,具有明显提升白细胞作用.%Objective To observe the clinical efficacy of ginger-partitioned moxibustion in treating myelo- suppression induced by chemotherapy for multiple myeloma (MM), and to discuss the effect of ginger-partitioned moxibustion in preventing and treating the adverse reactions of chemotherapy.Method Forty-four MM patients with myelosuppression induced by chemotherapy were randomized into a treatment group and a control group, 22 cases each. The treatment group was intervened by ginger-partitioned moxibustion, while the control group was intervened by oral administration of Leukogen tablets, both for 14 d. The white blood cell (WBC) count was observed before the treatment, on treatment day 7 and 14, and 1 week after the intervention; the incidence of nausea and vomit and clinical efficacies were compared between the two groups.Result The total effective rate was 81.8% in the treatment group versus 63.6% in the control group, and the difference was statistically significant (P<0.05). The WBC count on the 7th treatment day was significantly different from that before the treatment in both groups (P<0.05); the WBC count in the treatment group was significantly different from that in the control group on the 7th treatment day (P<0.05). The WBC count on the 14th treatment day was significantly different from that on the 7th day in both groups(P<0.05); the WBC count in the treatment group was significantly different from that in the control group on the 14th treatment day (P<0.05). The WBC count 1 week after the treatment was insignificantly different from that on the 14th treatment day in both groups (P>0.05); there was no significant difference in comparing the WBC count 1 week after the treatment between the two groups (P>0.05). The incidence of nausea and vomit in the treatment group was significantly lower than that in the control group after the treatment (P<0.05).Conclusion Ginger-partitioned moxi- bustion can effectively treat myelosuppression due to chemotherapy for MM, and it can significantly increase the WBC count.