大剂量阿托伐他汀对急性脑梗死患者血清炎性因子的影响

摘要

Objective To observe the influence of high-dose atorvastatin treatment on inflammatory factors in patients with acute cerebral infarction (ACI). Methods According to the results of carotid artery ultrasound, 136 cases of patients with ACI were divided into carotid vulnerable plaque group and carotid stable plaque group in each of which had 68 cases.34 cases were both randomly selected in two groups and given a small dose ( low-dose gtoup) and high dose atorvastatin (high-dose group) treatment. Blood lipoprotein, high sensitivity C-reactive protein (hs-CRP), interleukin-17 (IL-17) and marix metalloproteinase-9 (MMP-9) were detected before treatment and after treatment for 2 weeks. Results After treatment, levels of LDL-C, TG, TC, hs-CRP, IL-17 and MMP-9 were significantly decreased in both groups (P ＜0. 01 ),which in high-dose group were lower than those in low-dose group (P ＜ 0.05 or ＜ 0.01 ). Conclusion High-dose atorvastatin could rapidly reduce serum inflammatory factors in patients with ACI, thus might have the stronger.anti-inflammation function and improve the stability of vulnerable plaque.%目的 探讨大剂量阿托伐他汀对急性脑梗死(ACI)患者血清炎性因子的影响.方法 根据颈动脉超声结果,将136例ACI患者分为颈动脉斑块易损及斑块稳定各68例,两者均随机抽取34例分别给予小剂量(小剂量组)和大剂量(大剂量组)阿托伐他汀治疗.治疗前、治疗后2周检测患者的血脂、血清高敏-C反应蛋白(hs-CRP)、白细胞介素-17(IL-17)及基质金属蛋白酶-9(MMP-9).结果 治疗后,两组LDL-C、TG、TC、hs-CRP、IL-17和MMP-9均下降,大剂量组均低于小剂量组(P＜0.05或＜0.01).结论 大剂量阿托伐他汀能迅速降低ACI患者的血清炎性因子,具有更强的抗炎作用,可提高易损斑块的稳定性.