孕20～24周对子痫前期有预测作用的血清学标志物的Logistic研究

摘要

Objective To investigate whether such serological markers as erythrocyte sedimentation rate in 1 hour ( ESRI) , hemoglobin (Hh) , hematocnt (HCT) , platelet count ( PLT), and mean platelet volume ( MPV) could be uaed to predict preeclampsia at 20-24 weeks of gestation. Methods A total of 352 women at 20-24 weeks of gestation were selected, among which 66 patients with preeclampsia as case group, and 286 normal pregnant women as control group. Both univariate and multivariate analysis methods for case-control study were used to investigate predictive serological markers for preeclampsia through comparing ESRI, Hb, HCT, PLT and MPV of the two groups. Results Univariate analysis indicated that the differences in Hb, HCT, and MPV of the two groups had statistical significance (P <0.05 ). Multivariate analysis showed that Hb and MPV were clinical risk factors for preeclampsia (P < 0.05). Conclusion For patients at 20-24 weeks gestation, Hb, MPV are likely helpful to the prediction of preeclampsia.%目的 探讨1 h血沉(EsR1)、血色素(Hb)、红细胞压积(HCT)、血小板计数(PLT)及血小板平均体积( MPV)在孕20-24周是否可以对子痫前期起到预测作用.方法 选取孕20-24周孕妇共计352例,其中66例子痫前期患者为病例组,286例正常孕妇为对照组,采用单因素及多因素分析方法进行病例对照研究,比较ESR1、Hb、HCT、PLT及MPV等的差异,寻找该孕期对子痫前期有预测作用的血清学标志物.结果 采用单因素分析,病例组和对照组的Hb、HCT、MPV之间的差异有统计学意义(P均＜0.05).采用多因素分析,Hb、MPV为子痫前期患者的临床危险因素(P均＜0.05).结论 孕20～24周,Hb、MPV对子痫前期有一定的预测作用.