碱性成纤维细胞生长因子对碱烧伤兔眼角膜新生血管的影响

摘要

Objective To investigate the effect of basic fibroblast growth factor ( bFGF) on the promotion of neovscu-larization in alkali burned rabbit corneas .Methods Establishing the alkali burned rabbit corneas models , and then dev-ided them into two groups .In the experimental group , bFGF was injected into conjunctiva of rabbits every week before lefe eye cornea transplantation , and then observing the formation of new blood vessels of cornea to evaluate the effect of bFGF on the neovscularization .The right eye of rabbit as the control group , only establishing the alkali burned rabbit corneas models and performing the implantations of keratoprothsis .Results The amount of neovascularization in the rabbit's corneas in ex-perimental group was larger than that in contral group statistically ,before or after implantation; The transplantated kerato-prothesis of experimental group grew well , there were no severe complications occurred such as meltage and perforation . Conclusions bFGF has a significant effect on promotion of neovascularization in alkali burned rabbit corneas and decrea -sing the inflammatory reaction .%目的：观察碱性成纤维细胞生长因子（ bFGF）对碱烧伤兔眼角膜新生血管的影响。方法建立兔眼碱烧伤模型并行人工角膜移植术。兔左眼为实验组，移植人工角膜前后结膜下注射bFGF 1 U，1次／d。兔右眼为对照组，仅建立眼碱烧伤模型并行人工角膜移植术。观察两组角膜新生血管的形成情况。结果实验组角膜新生血管形成量大于对照组（ P＜0．01）；实验组兔眼角膜—人工角膜复合体生长良好，无一例发生角膜溶解穿孔、脱出等严重并发症。结论 bFGF能明显促进碱烧伤兔眼角膜新生血管的形成，减轻炎症反应。