卵巢癌组织中 CXCR4、MMP-9的表达变化及临床意义

摘要

Objective To observe the expression changes of CXC chemokine receptor 4 (CXCR4) and matrix metal-loproteinase 9 ( MMP-9) in ovarian carcinoma tissues, and to investigate their clinical significance.Methods The expres-sion of CXCR4 and MMP-9 in 60 cases of ovarian carcinoma ( group A) , 20 cases of borderline tumor ( group B) and 10 cases of benign tumor ( group C) was examined by immunohistochemical method.The correlation between them and their correlations with the clinicopathological parameters were analyzed.Results The positive expression rates of CXCR4 in the group A, group B and group C were 58.33%(35/60), 20.00%(4/20) and 10.00%(1/10), respectively.There was a statistically significant difference between group A and groups B and C (all P<0.05).The positive expression rates of MMP-9 in the group A, group B and group C were 83.33% (50/60), 35.00%(7/20) and 20.00% (2/10), respec-tively.Significant difference was found when we compared group A with groups B and C (all P<0.05).In ovarian carci-noma, the expression of CXCR4 protein was related with TNM stage and lymph-node metastasis;the expression of MMP-9 protein was related with tumor histological grade, TNM stage and lymph-node metastasis ( all P<0.05) .The CXCR4 ex-pression was positively correlated with the expression of MMP-9 in the ovarian carcinoma tissues (r=0.257, P<0.05). Conclusions The expression of CXCR4 and MMP-9 is increased in the ovarian carcinoma tissues, which may play an im-portant role in the carcinogenesis and development of ovarian carcinoma.The combined detection of CXCR4 and MMP-9 may provide scientific experimental evidence for targeted therapy.%目的：观察卵巢癌组织中CXC家族趋化因子受体4（CXCR4）、基质金属蛋白酶9（MMP-9）的表达变化，并探讨其意义。方法采用免疫组化法检测60例份卵巢癌（ A组）、20例份交界性肿瘤（ B组）、10例份良性肿瘤（ C组）组织CXCR4、MMP-9，并分析两者间及其与卵巢癌临床病理参数的相关性。结果 A、B、C组CXCR4阳性率分别为58．33％（35／60）、20．00％（4／20）、10．00％（1／10），A组分别与B、C组比较，P均＜0．05；MMP-9阳性率分别为83．33％（50／60）、35．00％（7／20）、20．00％（2／10），A组分别与B、C组比较，P均＜0．05。 CXCR4表达与卵巢癌TNM分期、淋巴结转移有关，MMP-9表达与卵巢癌组织学分级、TNM分期、淋巴结转移有关（P均＜0．05）。卵巢癌组织中CXCR4与MMP-9表达呈正相关（ r＝0．257，P＜0．05）。结论卵巢癌组织中CXCR4、MMP-9表达升高，其可能在卵巢癌的发生发展过程中起重要作用，联合检测二者可为寻找卵巢癌靶向治疗提供实验依据。