青年女性大肠癌患者癌组织中 ERβ、Bad 表达变化及意义

摘要

Objective To investigate the expression and significance of estrogen receptorβ( ERβ) and pro-apoptotic protein ( Bad) in the cancer tissues of young females with colorectal carcinoma.Methods The expression of ERβand Bad in the cancer tissues ( cancer group) and in para-carcinoma tissues ( para-carcinoma group) of 42 cases of young females with colorectal carcinoma was detected by immunohistochemical SP method.The relationship between them in colorectal carcinoma and their correlations with the clinicopathological parameters were analyzed.Results In the cancer group and para-carcinoma group, the positive expression rates of ERβwere 71.43%and 88.09%( P<0.05);and the positive ex-pression rates of Bad were 76.19%and 85.71%(P<0.05).The expression of ERβand Bad was associated with tumor differentiated degrees (all P<0.05).In the colorectal cancer tissues, the expression of ERβwas positively correlated with Bad expression (r=0.389, P<0.05).Conclusions The expression of ERβand Bad is decreased in the cancer tissues of young females with colorectal carcinoma, which may be closely associated with the occurrence and development of color-ectal carcinoma.The combined detection of them can be expected to become the new target for cancer prevention and treat-ment.%目的：观察青年女性大肠癌患者癌组织中雌激素受体β（ ERβ）、促凋亡蛋白（ Bad）表达变化，并探讨其意义。方法采用免疫组化SP法检测42例份大肠癌组织（大肠癌组）及42例份癌旁组织（癌旁组）中ERβ、Bad表达情况，并分析两指标间及其与大肠癌临床病理参数的关系。结果大肠癌组及癌旁组ERβ阳性率分别为71．43％、88．09％，两组比较，P＜0．05；Bad阳性率分别为76．19％、85．71％，两组比较，P＜0．05。 ERβ、Bad表达均与大肠癌肿瘤分化程度有关（P均＜0．05）。大肠癌组织中ERβ与Bad表达呈正相关（r＝0．389，P＜0．05）。结论青年女性大肠癌患者癌组织中ERβ、Bad表达降低，其可能与大肠癌的发生、发展相关，联合检测两者可望成为大肠癌预防、治疗的新靶点。