空腹血糖水平对缺血性脑卒中患者平均血小板体积的影响及意义

摘要

目的：观察空腹血糖（ FPG）水平对缺血性脑卒中（ IS）患者平均血小板体积（ MPV）的影响，并探讨其意义。方法选取IS患者522例（IS组）、Ⅱ型糖尿病患者115例（T2DM组）、健康体检者120例（对照组）。根据FPG水平将IS组分为4组：A组（3．89 mmol／L≤FPG＜5．0 mmol／L）222例，B组（5．0 mmol／L≤FPG ＜5．5 mmol／L）105例，C组（5．5 mmol／L≤FPG＜6．1 mmol／L）115例，D组（6．1 mmol／L≤FPG＜7．0 mmol／L）80例；A、B组为正常FPG组，C、D组为空腹血糖受损（ IFG）组（ C组为轻度IFG、D组为重度IFG）。检测各组FPG、血脂、肝肾功能、MPV，评价MPV与FPG、血脂、肝肾功能的关系。结果 A、B、C、D、T2DM组及对照组MPV分别为（8．55±0．72）、（8．88±0．86）、（8．92±0．90）、（9．12±0．96）、（12．23±1．36）、（8．63±0．72） fL；T2DM组均高于其他各组，P均＜0．01；C、D组均高于A、B组，D组增高更为显著，P均＜0．05。正常FPG组、IFG组、T2DM组FPG、年龄、UA、LDL-C与MPV均呈正相关（P均＜0．05）。多元线性回归分析显示，各组MPV与FPG均具有独立相关性（P均＜0．05）。结论 IS患者MPV随FPG升高而升高，MPV、血糖变化对其合并心脑血管疾病具有监测及预防作用。%Objective To observe the influence of fasting plasma glucose ( FPG) level on mean platelet volume (MPV) in patients with ischemic stroke (IS) and to explore its clinical significance .Methods A total of 522 patients with IS (IS group), 115 patients with type 2 diabetes (T2DM group) and 120 normal healthy persons (control group) were enrolled into this study .According to FPG levels , IS patients were divided into four groups: group A including 222 patients (3.89 mmol/L≤FPG<5.0 mmol/L), group B including 105 patients (5.0 mmol/L≤FPG<5.5 mmol/L), group C including 115 patients (5.5 mmol/L≤FPG<6.1 mmol/L) and group D including 80 patients (6.1 mmol/L≤FPG<7.0 mmol/L).Group A and B were the normal FPG group, group C and D were impaired fasting glucose (IFG) ( group C was mild IFG , group D was severe IFG ) .The parameters including FPG , blood lipids , liver and kidney func-tion, and MPV were obtained.Meanwhile, the correlations between MPV and any one of the above parameters were evalua -ted.Results MPV was (8.55 ±0.72), (8.88 ±0.86), (8.92 ±0.90), (9.12 ±0.96), (12.23 ±1.36) and (8.63 ±0.72) fL in the groups A, B, C, D, T2DM and control group, respectively.MPV of the T2DM group was significantly higher than that in any other groups ( all P<0.01).MPV of the groups C and D were higher than that in groups A and B . Moreover, MPV of group D increased more significantly (all P<0.05).MPV in the normal FPG group, IFG group and T2DM group was positively correlated with FPG , age, UA and LDL-C ( P<0.05).Multiple linear regression analysis showed that MPV in each group was independently correlated with FPG (all P<0.05).Conclusion MPV is increased in the IS patients with the increase of FPG , and it is of great significance for the surveillance and prevention of cardiovascular and cerebrovascular disease to pay close attention to MPV and blood glucose changes .