Objective To explore the role of integrin β-4 ( ITGβ-4) in the occurrence and development of colorectal cancer .Methods The expression of ITGβ-4 in 125 cases of colorectal cancer tissues ( cancer group , including 71 cases of colon cancer and 54 cases of rectal cancer ) , matching 75 cases of normal colorectal tissues ( normal group ) , and 28 cases of colorectal adenomas ( adenomas group ) were detected by immunohistochemical method .We analyzed the relationship of ITGβ-4 expression with clinicopathological parameters and survival of colorectal cancer patients .Results The high expres-sion rates of the normal group, adenomas group and cancer group were 6.67% (5/75), 14.29% (4/28) and 40.00%(50/125),respectively;and the high expression rate of ITGβ-4 in the colorectal cancer group was obviously higher than that of the normal group and adenoma group (all P<0.01).High expression of ITGβ-4 was closely associated with tumor differentiation, TNM stage and invasion depth (all P<0.05), but was not associated with tumor location , lymph node me-tastasis and survival time (all P>0.05).Among 66 patients with 5-year follow-up, the mean OS of 36 high expression ca-ses was 71.8 months and the mean OS of 30 low expression cases was 74.5 months (P>0.05).Conclusion The expres-sion of ITGβ-4 was increased in the colorectal cancer tissue and the abnormal expression might be associated with tumori -genesis and development of colorectal cancer .%目的：探讨整合素β-4（ITGβ-4）在结直肠癌发生、发展中的作用。方法选择结直肠癌组织125例份（肠癌组）及配对正常结直肠组织75例份（正常组），另选结直肠腺瘤组织28例份（腺瘤组）。采用免疫组化法检测各组ITGβ-4表达；分析结直肠癌组织中ITGβ-4表达与患者临床病理参数及生存期（ OS ）的关系。结果正常组、腺瘤组及肠癌组ITGβ-4高表达率分别为6．67％（5／75）、14．29％（4／28）、40．00％（50／125），肠癌组ITGβ-4高表达率明显高于正常组及腺瘤组（P均＜0．01），而正常组与腺瘤组比较无统计学差异（P＞0．05）。结直肠癌组织中ITGβ-4高表达与患者肿瘤组织分化程度、TNM分期、浸润深度有关（ P均＜0．05），与肿瘤发病部位、淋巴结转移、5年内预后无关（P均＞0．05）。有5年以上预后随访资料的66例患者中，ITGβ-4高表达者36例，平均OS为71．8个月；ITGβ-4低表达者30例，平均OS为74．5个月；二者比较P＞0．05。结论结直肠癌组织中ITGβ-4表达升高，其异常表达在结直肠癌的发生、发展过程中起促进作用。
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