绵羊 GDF9基因研究进展

摘要

开展绵羊多羔性状主效基因的研究，对于揭示绵羊高繁殖力的分子机制和利用分子标记辅助选择迅速提高绵羊的繁殖性能有重要意义。GDF9属于 TGFβ超家族成员，它主要由卵母细胞分泌，对卵泡的生长和分化、卵母细胞的减数分裂、成熟和胚胎的发育起重要的调节作用。因此，可以将 GDF9基因作为绵羊繁殖性状的候选基因来研究。本文就 GDF9基因、蛋白结构及其表达、生物学作用以及对绵羊繁殖力的影响等方面的研究进行总结回顾，并对其应用前景进行展望。%To reveal the molecular mechanism of high sheep fecundity and improve sheep reproduction performance by marker -assisted selection,it is necessary to carry out the researches on major genes affecting sheep fecundity.As a member of TGFβsuper family,GDF9 is secreted by oocyte,and plays an important role in the growth and differentiation of follicle,meiosis and maturation of oocyte,as well as embryo development. Thus GDF9 gene is considered as the candidate gene of sheep fecundity.The researches on gene structure, protein structure,expression,biological function and effects on sheep fecundity of GDF9 were summarized in this article,then its application prospect was anticipated.