Objective :Investigate the current clinical features ,Genus characteristics and distribution of invasive fungal infections in comprehensive ICU, in order to the reference for clinical treatment and degrade invasive fungal infections.Methods :Retrospective study the fungus-cultured positive cases among the patients in 4 years, according to the definite diagnosis of invasive fungal infections analyzed those cases, such as the patients age, potential disease, locations,species distribution and risk factors.Results: The rate of invasive fungal infection was 7.64 ％ in comprehensive ICU.Isolating rate from sputum and urine accounting for 67.45％ and 9.90％.The most common invasive fungal infection were Candida, accounting for 94.34％ ,among Candida albicans accounted for 51.89％.The factors related to invasive fungal infection were severity and multiplicity of illness, invasive monitoring and therapeutic tool , broad-spectrum antibiotic abuse , long term use of glucocorticoid , elderly patient with the severity of the potential disease, such as diabetes, chronic obstructive pulmonary disease(COPD) etc.Conclusion: The rate of invasive fungal infections increased in recent years in comprehensive ICU , Candida albicans are still the main pathogens.The infections incidence of non-C.albicans and the Aspergillus strains are increasing recent years, and has a raising tendency.so early diagnosis and experimental t reatment are very important.%目的:探讨当前综合重症加强病房(综合ICU)院内侵袭性真菌感染的临床状况,病原菌特性、分布,为临床治疗及减少真菌感染提供参考依据.方法:回顾性分析4年来真菌培养阳性住院患者病例资料,从患者年龄、病种、部位、菌种分布、易患因素等方面进行分析.结果:综合ICU中侵袭性真菌感染发生率7.64%;其中痰液检出率最高67.45%,其次尿液占9.90%;真菌感染以白色假丝酵母菌属占94.34%,是感染主要菌属,其中白色假丝酵母菌占51.89%,是感染主要菌种;易患因素主要有病情危重且复杂、应用侵入性监测和治疗手段、广谱抗菌药物的不合理使用、长期使用激素、老年患者合并糖尿病及慢性阻塞性肺部疾病等基础疾病等.结论:综合ICU侵袭性真菌感染近年呈上升趋势,其中白色假丝酵母菌是感染的主要病原菌,值得注意的是非白色假丝酵母菌和曲霉菌属引起的感染正在逐年增加,应重视早期诊断及合理治疗.
展开▼
