水通道蛋白1在结直肠癌中的表达及其与临床病理的相关性研究

摘要

Objcctivc:To discuss the expression of aquaporin l(AQPl) in colorcctal cancer and analyze its correlation with clinicaopathoiogicai. Methods:The AQP1 were detected by immunohistochemistry method in 81 cases with colorcctal cancer tissue samples and normal colorcctal tissue samples. Results: The ovcrcprcssion rate of AQP1 in colorcctal cancer tissue samples was significantly higher than that in normal colorcctal tissue samples. The expression ofAQPl was significantly associated with clinical stage and lymphoid node metastasis but showed no significant relationship with cell differential degree. Conclusion; AQP1 is ovcrexpresscd in colorcctal cancer tissues, which is a good index for colorcctal carcinogcncsis, progression and metastasis.%目的:探讨水通道蛋白1(AQP1)在结直肠癌中的表达,分析其与临床病理的相关性.方法:采用免疫组织化学方法检测81例结直肠癌和癌旁正常结直肠组织中水通道蛋白1(AQP1)的表达,分析其与临床病理资料间的相关性.结果:结直肠癌组织AQP1的高表达率明显高于癌旁正常结直肠组织.结直肠癌组织AQP1的高表达与临床分期和淋巴结转移密切相关,而与细胞分化程度无相关性.结论:AQP1在结直肠癌组织中呈高表达,是反映结直肠癌发生、发展及转移的一项良好指标.