血脂异常与2型糖尿病视网膜病变的关系探讨

摘要

目的:探讨糖尿病视网膜病变(DR)与血脂的关系.方法:将109例2型糖尿病患者按照有无糖尿病视网膜病变分为无视网膜病变(NDR)组56例,有视网膜病变(DR)组53例,DR组进一步分为背景型糖尿病视网膜病变(BDR)组38例和增殖型糖尿病视网膜病变(PDR)组15例,检测患者甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)水平,分析各组间上述指标的变化.结果:DR组患者病程、血清TG、TC、LDL-C、HbA1c水平显著高于NDR组(P<0.05);PDR组病程、血清TG、TC、LDL-C、HbA1c水平也显著高于BDR组(P<0.05).结论:DR的发生发展与血脂异常相关,检测血脂及治疗血脂异常对防止DR的发生发展有益.%Objective:To investigate the relationship between serum lipid and diabetic retinopathy in type 2 diabetes mellitus. Methods: According to retinopathy examination, 109 cases with type 2 diabetes mellitus were divided into the non-DR group(56cases) and the DR group(53 cases) , the DR group was further divided into background diabetic retinopathy(BDR) group(38 cases) and proliferative diabetic retinopathy(PDR) group(15cases). The fasting serum triglyceride(TG) , total cholesterol ( TC) , high-density lipoprotein cholesterol ( HDL-C) , low-density lipoprotein cholesterol(LDL-C) , HbAlc and fasting plasm glucose(FPG) were measured, and observed the changes in these indexs. Results:The course of disease,TG,TC, LDL-C,HbAlc in DR group were significantly higher than those in NDR group; The course of disease, TG, TC, LDL-C, HbAlc in PDR group were also significantly higher than those in BDR group(P<0. 05). Conclusion;The development and progression of DR relate to dyslipidemia. In order to avoid development and progression of DR caused by dyslipidemia, we should detect and control serum lipid in type 2 diabetes mellitus.