沙利度胺联合小剂量HA方案治疗老年急性髓系白血病23例

摘要

Objective:Observation of thalidomide combined with smll dose of HA regimen in the treatment of elderly acute myeloid leukemia :efficacy and safety .Methods:Retrospective analysis of receiving thalidomide combined with small dose of HA regimen in the treatment of elderly patients with the clinical dada of 23 caces with aml.Thalidomide100mg/d continuous oral,small dose of HA scheme of homoharringtonine(har)1~2mg/d ,intray-enou infusion , d1 ~14 .cytosine arabinoside(Ara-c) 25~50mg/d intravenous infusion, d1~14,14 days for1 courses .After the 1~2 treatment course evaluation of efficacy .lcourses of treatment achieved complete remission with conventional DA、MA、 EA plan of consolidation therapy ,on 2 successive treatment dose not relieve the latter replacement programme ,observation of treatment results and adverse reactions .Results; In 23 patients , complete remission in 7 cases ,partial remission in 9 cases ,CR rate 30 .4/o ,total efficiency 69 .2% .All patients were successfully completed chemotherapy ,adverse reaction in bone marrow suppression ,no serious infection ,bleeding and important organ injuries ,no early death cases .Conclusion :Thalidomide combined with small dose of HA regimen in the treatment of treatment of elderly AML curative effect is accurate ,sate ,well tolerated .%目的:观察沙利度胺联合小剂量HA方案治疗老年人急性髓细胞白血病(AML)的疗效及安全性.方法:回顾分析接受沙利度胺联合小剂量HA方案治疗的老年AML患者23例的临床资料.沙利度胺100mg/d连续口服,小剂量HA方案为高三尖杉酯碱(har)1～2mg/d,静脉滴注,d1～14.阿糖胞苷(Ara-c)25～50mg/d静脉滴注,d1～14.14d为1疗程.1～2疗程结束后评价疗效.治疗1疗程达完全缓解者用常规DA、MA、EA等方案进行巩固治疗,连用2疗程不缓解者则更换方案.观察治疗效果及不良反应.结果:23例患者中,完全缓解7例,部分缓解9例,CR率30.4%,总有效率69.2%.所有患者均顺利完成化疗,不良反应除骨髓抑制外,无严重感染、出血及重要脏器损伤,无早期死亡病例.结论:沙利度胺联合小剂量HA方案治疗老年人AML疗效确切,相对安全,耐受性好.