多索茶碱治疗小儿毛细支气管炎150例疗效观察

摘要

Objective :To investigate the therapeutic effect of doxofylline in infants with bronchiolitis . Methods :All 238 infants who were diagnosed with bronchiolitis were randomly divided into two groups ,150 cases in treatment group and 88 cases in control group .These groups received routine medical treatment ,and the treatment group was given doxofylline and the control group was given theophylline .Observe and record clinical characteristics and adverse reactions in two groups every day and analyze these results with statistical methods .Results :The total effective rate in the treatment group is 96 .7% and 84 .1% in the control group .These total effective rates of two groups were statistically differences (P < 0 .05) .Moreover ,the extinction time of wheezing ,accelerated breathing and pulmonary rales and the time of hospitalization were statistically significant differences (P< 0 .01) .Conclusion :Therapeutic effect of doxofylline is obvious in infants with bronchiolitis .It could significantly decrease the extinction time of clinical symptoms .Because of features and safety ,doxofylline is worth popularizing .%目的：探讨多索茶碱治疗小儿毛细支气管炎的临床疗效。方法：将238例毛细支气管炎患儿随机分为干预组150例和对照组88例，两组患儿均给予相同的常规治疗以及对症支持，干预组在此基础上加用多索茶碱，对照组加用氨茶碱。每日观察并记录两组患儿的症状、体征和不良反应等情况并进行统计分析。结果：干预组的治疗总有效率为96．7％，对照组治疗总有效率为84．1％，两组总有效率比较有显著性差异（P＜0．05），且两组患儿的喘憋、气促和肺部啰音等体征和临床症状的消失时间以及住院时间存在极显著性差异（P＜0．01）。结论：多索茶碱在治疗婴幼儿毛细支气管炎中可明显改善临床症状的消失时间，且安全有效。