2型糖尿病患者服用阿司匹林后MPV变化的临床观察

摘要

Objective :To investigate the association of Mean platelet volume (MPV) with type 2 diabetes mellitus on Aspirin .Methods :The study was conducted on the 67 type 2 diabetes mellitus at Yan’an hospital of tra‐ditional Chinese medicine hospital August 2012 and December 2013 ,M PV were calculated in the type 2 diabetes mel‐litus before and after 6 month aspirin(100mg/d )and plus metformin (50 mg ) and dimethylbiguanide treaed .Re‐sults :MPV was significantly lowered after aspirin(75mg/d )and aspirin(75mg/d )and dimethylbiguanide treaed than that of not treated(t= 1 .03 ,P= 0 .009 ;t= 1 .57 ,P = 0 .012) .The serum glucose concentration was not significantly different with aspirin(75mg/d )treated or not(t= 6 .28 ,P= 0 .76) .Conclusion :The results suggest M PV is reduced after aspirin100mg/d treaed with type 2 diabetes mellitus .%目的：探讨 M PV 在2型糖尿病患者应用阿司匹林治疗前后的变化。方法：将67例首次确诊为2型糖尿病患者根据采用单纯阿司匹林治疗（36例）及阿司匹林加二甲双胍治疗（31例）两组，分别检测其治疗前及治疗6个月后 MPV 水平。结果：阿司匹林加二甲双胍及单纯阿司匹林治疗6个月后患者 M PV 水平明显低于治疗前（t＝1．03，P＝0．009；t ＝1．57，P＝0．012），单纯采用阿司匹林治疗前、后患者血糖无明显差异（t＝6．28，P＝0．76）。结论：阿司匹林治疗可显著降低2型糖尿病 MPV 水平。