Objective To assess the value of platelet aggregation function and urinary 11-dehydro-thromboxane B2 for recurrent angina pectoris patients on aspirin. Methods 48 patients with recurrent stable angina pectoris and 50 patients with once stable angina pectoris took aspirin( 100 mg/d )for at least 7 days. The patients' platelet aggregation function were evaluated and urinary 11-dehydro TXB2 levels were meas-ured. Results Platelet aggregation function evaluated by arachidonic acid was significantly different between recurrent stable angina pectoris patients and only once stable angina pectoris patients( P < 0. 01 ); 11-de-hydro-TXB2 levels of patients who were aspirin nonresponder was significantly higher than that of aspirin sen-sitive patients( P <0.01 ). Conclusion Urinary 11-dehydro-TXB2 level and platelet aggregation function of the patients on aspirin should be measured.%目的 评价血小板聚集功能和尿11-脱氢血栓素B2在评定反复心绞痛患者服用阿司匹林方面的价值.方法 48例反复心绞痛患者和50例一次心绞痛患者服用阿司匹林(100 mg/d)至少7 d以上,测定血小板聚集功能和尿11-脱氢-血栓素B2的含量.结果 花生四烯酸作诱导剂时,反复心绞痛患者与一次性心绞痛患者相比其血小板聚集功能的差异有统计学意义(P<0.01);反应敏感者尿11-脱氢血栓素B2与反应不敏感者相比其差异有统计学意义(P<0.01).结论 服用阿司匹林后,需检测血小板聚集功能和尿11-脱氢-血栓素B2.
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