COX-2、EGFR在非小细胞肺癌中的表达机制

摘要

Objective :Investigate the expressions of cyclooxygenase‐2(COX‐2) and epidermal growth fac‐tor receptor(EGFR) proteins in non‐small cell lung cancer .Method:COX‐2 and EGFR proteins were detected by im‐munohistochemical in 80 NSCLC tissues and 25 normal lung tissues .Result :Cox‐2 and EGFR protein positive rates were 67 .5% 、71 .3% .Significant differences were both present between COX‐2 and EGFR proteins positive rates of NSCLC(P<0 .05) .The positive rates of COX‐2 and EGFR protein were associated with tumor differentiation ,TNM stages and lymph node metastases(P<0 .05) .Conclusion:Overexpressions of COX‐2 and EGFR and proteins were detected in non‐small cell lung cancer ,and both promote cooperatively the development ,progress and metastas of NSCLC .%目的：探讨环氧合酶‐2（COX‐2））和表皮生长因子受体（EGFR）在人非小细胞肺癌组织中的表达机制。方法：应用免疫组织化学二步法检测80例非小细胞肺癌（NSCLC ）癌组织和25例正常肺组织中COX‐2和EGFR蛋白的表达。结果：COX‐2、EGFR蛋白在非小细胞肺癌中的阳性率分别为67．5％、71．3％。肺癌组织中COX‐2、EGFR蛋白的阳性率与正常肺组织相比，差异具有统计学意义（P＜0．05）。COX‐2、EGFR蛋白表达与肿瘤组织分化程度、TNM 分期、有无淋巴结转移密切相关（P＜0．05）。结论：COX‐2和EGFR蛋白在非小细胞肺癌中呈高表达，两者可能共同促进非小细胞肺癌的发生、发展和转移。