血清25-OH-D3水平与儿童哮喘急性发作和毛细支气管炎相关性研究

摘要

目的:探讨血清25-羟基维生素D3(25-OH-D3)水平与儿童哮喘(BA)急性发作和毛细支气管炎相关性.方法:选择BA急性发作患儿78例作为哮喘组,同期毛细支气管炎患儿72例作为毛支组,健康体检儿童75例作为对照组.检测3组血清25-OH-D3及TIgE水平.结果:与对照组相比,哮喘组和毛支组患儿血清25-OH-D3明显下降、TIgE显著上升(P<0.05),且病情越严重变化幅度越大;Pearson分析显示:哮喘组和毛支组血清25-OH-D3与TIgE水平均呈明显负相关(P<0.05).结论:儿童BA与毛支组患儿均存在血清25-OH-D3缺乏,且与病情程度密切相关.%Objective:To study the correlation among serum 25-OH-D3, acute episode of BA and bronchiolitis in children, and to provide clinical evidence for the treatment of asthmatic disease in children.Methods:78 cases of children with BA were selected as the asthma group, 72 cases of children with capillary bronchitis were selected as the bronchiolitis group, another 75 cases of healthy children were selected as the control group.The serum levels of 25-OH-D3 and TIgE were detected in 3 groups of children, and carried on the statistical comparison.Results:Compared with the control group, serum 25-OH-D3 of the asthma group and the bronchiolitis group decreased significantly, TIgE increased significantly (P<0.05), and the more serious illness,the greater the magnitude of change.Pearson correlation analysis showed that the levels of 25-OH-D3 and TIgE in the asthma group and the bronchiolitis group were negatively correlated (P<0.05).Conclusion:BA and bronchiolitis in children are lack of serum 25-OH-D3, and is closely related with the severity of the disease.