MR体素内不相干运动扩散加权成像对肺部良、恶性占位的鉴别诊断价值

摘要

Objective:To evaluate the role of intravoxel incoherent motion of diffusion weighted imaging in the differential diagnosis of lung lesions .Methods:Forty patients with lung masses (14 benign ,26 malignant were confirmed by pathology ) were undergone enhanced CT scanning were included in this retrospective study .All pa-tients were undergone conventional MRI and IVIM-DWI examination of the chest .The MTKL post-processing soft-ware was used to calculate the value of ADC ,D ,D* and f of the benign and malignant lesions ,which were recorded and compared .T test was used to compare the difference of the values of different parameters .Results :Benign le-sions and lung cancer ADC values were (1242 .22 ± 261 .16) × 10-6 mm2/s ,(820 .62 ± 238 .69) × 10-6 mm2/s respec-tively ,D values were (1178 .0±462 .6)×10-6mm2/s ,(854 .6±302 .6)×10-6mm2/s ,and f values were (0 .45192± 0 .17260) ,(0 .28397 ± 0 .14539) ,and the difference was statistically significant (P<0 .05);D* values were (26860 ±40505)×10-6mm2/sforthebenignlesionsand(22810±37930)×10-6mm2/sforthemalignantrespectively,the difference was not statistically significant (P>0 .05) .Conclusions :The intravoxel incoherent motion based on diffu-sion weighted imaging is useful for distinguishing between the benign and malignant lung lesions .%目的:探讨MR体素内不相干运动扩散加权成像对肺部良、恶性占位的鉴别诊断价值.方法:对40例肺部占位患者(经病理证实良性者14例,恶性者26例)进行回顾性研究,所有患者行胸部常规序列(T1 WI,T2 WI)及IVIM-DWI检查.并用后处理软件进行后处理,得到良、恶性病变的ADC值、D(扩散系数)、D*(灌注相关扩散系数)、f(灌注分数)值,采用独立样本t检验比较良、恶性占位各参数的差异.结果:肺良性占位ADC值:(1242.22±261.16)×10-6 mm2/s;D值:(1178.0±462.6)×10-6 mm2/s;f值:(0.45192±0.17260);肺恶性占位ADC值:(820.62±238.69)×10-6 mm2/s,D值:(854.6±302.6)×10-6 mm2/s,f值:(0.28397±0.14539);两组间差异均有统计学意义(P<0.05);肺良性占位D*值:(26860±40505)×10-6 m m2/s,肺恶性占位D*值:(22810±37930)×10-6 mm2/s,两组间差异无统计学意义(P>0.05).结论:在肺部良性病变与恶性肿瘤的鉴别诊断中,IVIM、DWI的参数ADC值、D值及f值有一定临床意义.