解郁丸联合帕罗西汀治疗卒中后抑郁临床研究

摘要

目的:探讨解郁丸联合帕罗西汀治疗卒中后抑郁的临床疗效.方法:选取卒中后抑郁患者90例,按照随机数字表法,随机分为研究组和对照组各45例,两组患者均给予控制血压、保护神经、营养脑细胞等常规支持治疗,对照组使用帕罗西汀治疗,研究组在此基础上使用解郁丸进行联合治疗,12周为一个疗程.比较两组临床疗效,并观察两组患者治疗前后汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)、美国国立卫生研究院卒中量表(NIHSS)评分情况,应用SF-36量表对两组生活质量进行评分,比较治疗过程中两组患者不良反应情况.结果:研究组治疗总有效率(93 .33%)优于对照组(82 .22%) ,差异显著(P＜0 .05) ;治疗前,两组HAMD评分无明显差异(P＞0 .05) ,治疗后,研究组治疗后2 、4 、8 、12周 HAMD评分低于对照组( P＜0 .05) ;治疗前,两组SDS和NIHSS评分水平无明显差异(P＞0 .05) ,治疗后,两组指标均有所改善,且研究组SDS和NIHSS评分下降程度较对照组明显(P＜0 .05) ;研究组患者生活质量各方面评分均优于对照组,差异有统计学意义(P＜0 .05) ;两组不良反应发生情况无明显差异(P＞0 .05).结论:解郁丸联合帕罗西汀治疗卒中后抑郁的临床疗效显著,明显改善患者抑郁状态,提高患者生活质量.%Objective :To explore the clinical effect of Jieyu pill combined with paroxetine in the treatment of post-stroke depression .Methods :90 cases of patients with depression after stroke ,according to the stochastic indicator method , each 45 cases were randomly divided into observation group and control group ,two groups of patients were given control of blood pressure ,protecting nerve ,regular support treatment ,such as nutrition brain cells in the control group treated with paroxetine ,observation group on the basis of using Jieyu pill combination therapy ,12 weeks for a period of treatment . Compare two groups of clinical curative effect ,and observe two groups before and after treatment in patients with Hamilton depression scale (HAMD) ,depression self rating scale (SDS) ,the national institutes of health stroke scale (NIHSS) scores ,application of SF-36 scale on two groups of quality of life score ,compared two groups of patients with adverse re-actions during the process of treatment .Results :The total effective rate (93 .33%) was superior to the control group (82. 22%) ,and the difference was significant (P＜0 .05).Before treatment ,there was no significant difference in HAMD scores between the two groups (P＞0 .05).After treatment ,the HAMD score of 2 ,4 ,8 and 12 weeks after treatment was lower than the control group ,and the difference was statistically significant (P＜0.05).Before treatment ,there was no significant difference between the two groups of SDS and NIHSS scores (P＞0.05).After treatment ,both groups showed improvement ,and the decrease of SDS and NIHSS scores was significantly lower than that in the control group (P＜0.05). Observation group of patients in the physiological function ,physiological functions ,physical pain ,general health ,vitality , social function ,emotional ,mental health ,only scores were better than that in control group (P＜ 0.05) ;the incidence of adverse reactions (11.11%) and the control group (13.33%) were not statistically significant (P＞0 .05).Conclusion :the clinical curative effect of Jieyu pill combined with paroxetine in the treatment of post-stroke depression was significant ,sig-nificantly improved the depressive state of patients ,and no adverse reactions increased .