双黄连联合阿奇霉素治疗小儿肺炎支原体的效果及对患者免疫功能、炎症反应的影响

摘要

目的:探讨双黄连联合阿奇霉素(AZM )对肺炎支原体(M P )患儿的治疗效果及对免疫功能、炎症反应的影响.方法:选取200例M P患儿,其中联合组采用双黄连联合AZM+基础治疗措施,对照组仅采取AZM+基础治疗措施,两组各100例;治疗两个疗程后进行临床效果的比较.结果:联合组患儿的咳嗽、发热、肺部啰音消失时间均显著短于对照组(P＜0 .05) ;治疗前,两组患儿的血清MCP-4 、MDC 、IL-6 、IL-8 、IL-10 、TNF-α 、CD3+、CD4+、CD8+水平差异无统计学意义(P＞0 .05) ;治疗后,联合组患儿的血清MCP-4 、MDC 、IL-6 、IL-8 、IL-10 、TNF-α 、CD8+水平显著低于对照组(P＜0 .05) ,CD3+、CD4+水平高于对照组(P＜ 0 .05) ;治疗后,两组患儿的血清 MCP-4 、MDC、IL-6、IL-8、IL-10、TNF-α、CD8+水平较本组治疗前均显著降低(P＜ 0 .05),两组的CD3+、CD4+较治疗前显著升高( P＜ 0 .05 ) ;治疗后,联合组患儿痊愈62 .86%、显效28 .57%、好转8 . 57%,对照组痊愈44 .29%、显效32 .86%、好转21 .43%,两组比较差异具有统计学意义( P＜0 . 05) .结论:双黄连联合AZM 对M P患儿治疗效果更好,能进一步控制患儿的炎症反应,改善免疫功能.%Objective :To investigate the effect of shuanghuanglian combined with azithromycin (AZM ) on immune function and inflammation in children with mycoplasma pneumoniae (MP) .Methods :140 children with MP were collected ,and the combined group was treated with Shuanghuanglian combined with AZM ,while the control group only took AZM basic treatment measures ,The two groups of 70 cases ;treatment of two courses of clinical ef-ficacy comparison .Results :The cough ,fever ,and the disappearance of pulmonary rales in the combined group were significantly shorter than those in the control group (P＜0 .05) .Before treatment ,the serum MCP-4 ,MDC ,IL-6 ,IL-8 ,IL-10 ,TNF-α ,CD3+,CD4+,CD8+levels of the two groups were not significantly different (P＞0 .05) ;After treat-ment ,serum MCP-4 ,and group MDC ,IL-6 ,IL-8 ,IL-10 ,TNF-α ,CD8+level was significantly lower than that of con-trol group (P＜0 .05) ,CD3+,CD4+levels higher than the control group (P＜0 .05) ;After treatment ,the serum lev-els of MCP-4 ,MDC ,IL-6 ,IL-8 ,IL-10 ,TNF-alpha and CD8+in the two groups were significantly lower than those in the group before treatment (P＜0 .05) ,and CD3+and CD4+in the two groups were significantly higher than those before treatment (P＜0 .05) ;After treatment ,the combination group were cured in 62 .86%,effective in 28 .57%, improved in 8 .57%,the control group was 44 .29%,effective in 32 .86%,improved in 21 .43%,with significant differences between the two groups (P＜0 .05) .Conclusion :Shuanghuanglian combined with AZM for treatment of children with MP better ,inflammatory reaction can be controlled in children ,improve the immune function .