小儿肺咳颗粒结合糖皮质激素治疗儿童肺炎临床研究

摘要

Objective:To study the clinical efficacy and safety of glucocorticoid combined with Xiao'er Feike granule in the treatment of pneumonia in children.Methods:112 cases of children with pneumonia was studied, which were randomly divided into experimental group and control group(n=56),control group used glucocorticoid treatment,experimental group gave Xiao'er Feike granule treatment on the basis of the control group,treatment for 2 weeks,the clinical curative effect,the children with pulmonary function(FEV1/FVC,PEF and MBC),inflammatory markers(IL-2,IL-6)and adverse reactions of 2 group were observed.Results:the total effective rate of the experi-mental group(96.4%)was significantly higher than the control group(78.6%),with statistical significance(P<0.05);FEV1/FVC,PEF and MBC of experimental group were significantly higher than the control group,with sta-tistical significance(P< 0.05);IL-2,IL-6 of experimental group was significantly lower than that of control group, with statistical significance(P< 0.05);2 groups had no nausea,headache,drowsiness,dry mouth,mild stuffy nose, chest tightness,heart palpitations,tremor,adverse reactions such as anaphylactic shock drugs.Conclusion:glucocor-ticoid combined with Xiao'er Feike granule in the treatment of children pneumonia in order to effectively improve the patient's lung function and ease the inflammatory response,safe and reliable%目的:探讨糖皮质激素结合小儿肺咳颗粒治疗儿童肺炎的临床疗效及安全性.方法:选取112例儿童肺炎进行研究,随机分为治疗组和对照组各56例,对照组采用糖皮质激素治疗,治疗组在对照组的基础上进行小儿肺咳颗粒治疗,治疗两周时间,观察两组患儿的临床疗效、肺功能(FEV1/FVC、PEF和MBC)、炎性指标(IL-2、IL-6)及不良反应.结果:治疗组的总有效率(96. 4%)明显高于对照组(78.6%),差异具有统计学意义(P<0.05);治疗组的 FEV1/FVC、PEF 和M BC明显高于对照组,差异具有统计学意义(P<0.05);治疗组的IL-2、IL-6水平明显低于对照组,具有统计学意义(P<0.05);两组患儿均无恶心、头疼、口干、嗜睡、鼻塞、轻度胸闷、心悸、手抖、过敏性休克等药物不良反应.结论:糖皮质激素结合小儿肺咳颗粒治疗儿童肺炎可以有效改善患者的肺功能,缓解炎性反应,安全可靠.