三种食用油及三油酸甘油酯对小鼠血脂水平的影响

摘要

分别用含猪油、花生油、橄榄油或三油酸甘油酯的高胆固醇乳剂或单用高剂量食用油给小鼠灌服，比较各油脂对血脂的影响。结果表明，灌服含各食用油或三油酸甘油酯的高胆固醇乳剂后，小鼠血清总胆固醇（TC）、肝脏指数明显升高，血清总甘油三酯（TG）含量降低。单独灌服食用油后，三种油均引起小鼠 TC 水平升高；三种油和三油酸甘油酯均引起血清高密度脂蛋白胆固醇（HDL －C）和低密度脂蛋白胆固醇（LDL －C）水平升高，体重增加；除花生油外，其他油脂均升高肝脏指数。猪油、花生油和橄榄油与胆固醇合用均引起血中总胆固醇的升高；高油摄入并未引起高甘油三酯血症；花生油不易使脂质在肝脏积聚；三油酸甘油酯单独使用升高 TC 作用不明显，和胆固醇合用后其对血中总胆固醇的升高未见有改善作用。%The effects of lipin on blood lipid were compared by gavaging mice with lard,peanut oil,olive oil or the triolein with high cholesterol emulsions or high dose of one of the edible oils,respectively. Results showed that the serum total cholesterol (TC)and liver index increased significantly,and the level of total triglyceride (TG)in serum decreased,after the mice were gavaged with one of the three edible oils or the triolein with high cholesterol emulsions.After being gavaged with one of the three oils,TC of the mice was increased by each of the oils.The serum levels of high density lipoprotein cho-lesterol (HDL -C),low density lipoprotein cholesterol (LDL -C)and body weight were all increased because of the three oils or triolein.Meanwhile,olive oil,lard and triolein increased the liver index.In conclusion,lard,peanut oil,or olive oil mixed with cholesterol can increase serum total cholesterol lev-el;however,there was no evidence showing that high dose of oils caused hypertriglyceridemia;peanut oil was most not likely to cause fat accumulation in the liver;triolein has no obvious influence on in-creasing TC,and no significant improving effect on the rise of total cholesterol level caused by choles-terol mixed with oils.