t9，t11－CLA 抗大鼠氧化应激损伤的机理研究

摘要

以大鼠为研究对象，以大鼠血清和肝组织中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH －Px）活性和丙二醛（MDA）含量为指标，研究 t9，t11－CLA 的体内抗氧化作用效果。结果表明，喂养4周后，t9，t11－CLA 添加组中的中剂量组、高剂量组大鼠血清和肝组织中的 SOD 和 GSH－Px 活性明显高于正常组（P ＜0．05），MDA 含量的变化则与之相反，说明 t9，t11－CLA 对大鼠氧化应激损伤有较好的的保护作用，且产生这种保护作用的原因一方面是激活了机体抗氧化酶类，另一方面与 t9，t11－CLA 的抗氧化能力有关。%The antioxidant effect of t9,t1 1 -CLA was investigated based on the indicators of the ac-tivities of superoxide dismutase (SOD),glutathione peroxidase (GSH -Px)and the content of ma-londialdehyde (MDA)in rats serum and liver tissue.The results showed that after feeding for 4 weeks,the activities of SOD and GSH -Px in the serum and liver tissues of middle and high dose group were distinctly higher than that of control group(P <0.05 ),while the change of the content of MDA was opposite,which indicated that t9,t1 1 -CLA had good protective effect on oxidative stress injury in rats and this protective effect came from their own antioxidant capacity as well as the activa-ted antioxidant enzymes of the body.