辅助生殖治疗中9号染色体倒位的临床意义

摘要

目的:探讨9号染色体倒位在辅助生殖治疗中的临床意义.方法:回顾性分析9号染色体倒位患者的IVF/ICSI-ET生育结局,与同期夫妻染色体均正常患者进行比较.结果:不育夫妇一方9号染色体倒位的23对共进行23个周期的IVF/ICSI-ET治疗,平均获卵数10.6±6.0枚,受精率81.22％,卵裂率93.97％,有效胚胎形成率80.21％,胚胎种植率40.00％,临床妊娠率52.63％,流产率20.00％,与对照组230个周期的平均获卵数(10.7±5.9枚)、受精率(75.85％)、卵裂率(92.36％)、有效胚胎形成率(79.06％)、胚胎种植率(25.15％)、临床妊娠率(33.91％)、流产率(11.86％)相比均无统计学差异(P＞0.05).结论:9号染色体倒位患者辅助生殖技术助孕后结局与普通人群相比未见明显差异.%Objective:To determine if inversion of chromosome 9 could change the outcome of reproductive treatment in the infertile patients.Methods:A retrospective analysis was performed,the outcome between inv(9) couples (study group) and normal karyotype couples (the control) was compared.Results:Totally,23 cycles of study group and 230 cycles of control group were included.No.of oocytes retrieved,fertlization rate,cleavage rate,rate of effective embryo formation,implantation rate,clinical pregnancy rate and abortion rate in study group and the control were 10.6 ± 6.0 vs 10.7 ± 5.9,81.22％ vs 75.85％,93.97％ vs 92.36％,80.21％ vs 92.36％,40.00％ vs 25.15％,52.63％ vs 33.91％,20.00％ vs 11.86％,respectively.There were no significant differences between the two groups (P＞0.05).Conclusion:The outcome of inv(9) infertile patient treated by IVF/ ICSI-ET was similar to normal karyotype patients.