Objective To develop a new contraceptive implant containing gestodene featuring with only one rod for 5 years long effectiveness and safety. Methods Gestodene synthesis, polymer tube designation, in vitro or in vivo test, the pilot test was used for the establishing of minimum clinic dosage. Results It had a burst effect at beginning and become constantly releasing since 12th day. It had zero-order releasing, in vitro, the average releasing rate was 17.0-19.1 μg/d, the safe dosage was 70.2mg/kg, C1hr was 2.91 ± 1.25 ng/ml, Tmax was 8.86 ± 4.32 h, Cmax was 7.31 ± 1.09 ng/ml, Tss was 14 d,Css was 4.16 ± 0.48 ng/ml. Twenty-four hours later after removal of the implant, gestodene was almost cleaned out in the blood circulation and only trace amount of drug was detected after the removal. Conclusion One rod gestodene implant is a new long effective contraceptive and may be promising.
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机译:Conhecimentos sobre o uso de contraceptivos e prevenção de DsT: a percepção de mulheres imigrantes Knowledge of contraceptive methods and sTD prevention among immigrant women
机译:避孕普及率调查:模型调查问卷(Encuesta de prevalencia del Uso de anticonceptivos:Cuestionario modelo)(Etude de predominance des methodes Contraceptives:Questionnaire modele)